Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease?
Received Date: November 10, 2018; Published Date: November 27, 2018
Objective: To study the role of interstitial cells of Cajal (ICC) in the pathogenesis of gastro-intestinal motility disorders in Parkinson’s disease (PD).
Methods: The distribution of ICCs was studied by immunohistochemical analysis using anti c-kit antibodies in 4 cases of PD patients and 4 paired non-PD patients.
Results: ICCs were located in the inner part of the circular muscle and around the myenteric plexus between the two muscle layers. The number of c-kit+ ICCs was remarkably reduced or even disappeared in patients with PD.
Conclusion: The lack of ICCs may lead to the abnormal spontaneous electrical activity and conduction which gives rise to gastrointestinal motility disorders in PD.
Keywords: Parkinson’s disease; Gastro-intestinal motility disorders; Interstitial cells of Cajal