Could Abnormal Distribution of Interstitial Cells of
Cajal be Involved in Gastrointestinal Disorders in
Patients with Parkinson’s Disease?

HOU Miaomiao; MAO Xiaowei; LIU Yanqun; HOU Xiaojun; BI Xiaoying

Short Communication

Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease?

HOU Miaomiao¹, MAO Xiaowei¹, LIU Yanqun, HOU Xiaojun* and BI Xiaoying

¹HOU miaomiao and MAO xiaowei contributed equally to this article, china

Corresponding Author

Received Date: November 10, 2018; Published Date: November 27, 2018

Abstract

Objective: To study the role of interstitial cells of Cajal (ICC) in the pathogenesis of gastro-intestinal motility disorders in Parkinson’s disease (PD).

Methods: The distribution of ICCs was studied by immunohistochemical analysis using anti c-kit antibodies in 4 cases of PD patients and 4 paired non-PD patients.

Results: ICCs were located in the inner part of the circular muscle and around the myenteric plexus between the two muscle layers. The number of c-kit+ ICCs was remarkably reduced or even disappeared in patients with PD.

Conclusion: The lack of ICCs may lead to the abnormal spontaneous electrical activity and conduction which gives rise to gastrointestinal motility disorders in PD.

Keywords: Parkinson’s disease; Gastro-intestinal motility disorders; Interstitial cells of Cajal

Article Details

Citation

NHOU Miaomiao, MAO Xiaowei, LIU Yanqun, HOU Xiaojun, BI Xiaoying. Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease?. Arch Neurol & Neurosci. 1(5): 2018. ANN.MS.ID.000525.