Open Access Short Communication

Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson’s Disease?

HOU Miaomiao1, MAO Xiaowei1, LIU Yanqun, HOU Xiaojun* and BI Xiaoying

1HOU miaomiao and MAO xiaowei contributed equally to this article, china

Corresponding Author

Received Date: November 10, 2018;  Published Date: November 27, 2018


Objective: To study the role of interstitial cells of Cajal (ICC) in the pathogenesis of gastro-intestinal motility disorders in Parkinson’s disease (PD).

Methods: The distribution of ICCs was studied by immunohistochemical analysis using anti c-kit antibodies in 4 cases of PD patients and 4 paired non-PD patients.

Results: ICCs were located in the inner part of the circular muscle and around the myenteric plexus between the two muscle layers. The number of c-kit+ ICCs was remarkably reduced or even disappeared in patients with PD.

Conclusion: The lack of ICCs may lead to the abnormal spontaneous electrical activity and conduction which gives rise to gastrointestinal motility disorders in PD.

Keywords: Parkinson’s disease; Gastro-intestinal motility disorders; Interstitial cells of Cajal

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