Open Access Case Report

A Case Report of Severe Intrahepatic Cholestasis of Pregnancy with Severe Liver Damage as the Main Manifestation

Guolin He1,2, Xibiao Jia1,2, Ran Cheng1,2, Jinfeng Xu1,2, Yu Xuan1,2 and Bing Peng1,2*

1West China Second University Hospital, Sichuan University, China

2Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, China

Corresponding Author

Received Date:June 25, 2021;  Published Date: July 13, 2021


Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder during pregnancy. Most ICP cases have good prognosis after delivery. The mother’s ICP symptoms and biochemical abnormalities usually resolve after delivery.

Case: This was a severe ICP with severe liver damage as the main manifestation. One week after childbirth, her liver damage did not gradually recover but gradually worsened. This case showed quite difference from the common ICP cases. We have not found similar case reports.

Conclusion: The particularity of the onset and outcome of this case, compared with the conventional ICP case, which gives us a new perspective on ICP.

Keywords: ICP; Pregnancy; Prognosis; Bile acids; Liver transaminases aspartate aminotransferase; Liver alanine aminotransferase

Abbreviations: ICP: Intrahepatic Cholestasis of Pregnancy; AST: transaminases aspartate aminotransferase; ALT: Alanine Aminotransferase; GDM: Gestational Diabetes Mellitus; LDH: Lactate Dehydrogenase; IgG: Immunoglobulin G; D1L1: Drug-induced Liver Injury; AIH: Autoimmune Hepatitis; AFLP: Acute Fatty Liver of Pregnancy

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