Long Term Survival after TAVR in Western Denmark: A Multicentre Observational Study

Background: Transcatheter aortic valve replacement (TAVR) has proven a favorable treatment for patients with aortic stenosis for both lowand high-risk patients regarding complications and mortality associated with the procedure. All though clinical in-hospital outcomes seem favorable, the long lasting durability and the associated mortality is still debatable. In Denmark, we implanted the first TAVR in 2007 with all cardiac procedures registered in a large database, why we decided to look into the long-term results of TAVR in Denmark.

Method: A register based retrospective follow-up study, based on data from the Western Danish Heart Registry, which includes all TAVR-treated patients in the western part of Denmark. The primary outcome was all-cause mortality, while secondary endpoint were evaluations whether other factors as procedure-year, type of valve, and access-route had an impact on long-term outcomes.

Result: One-thousand-six-hundred-and-seventy-five patients were included. Lower age as well as transfemoral access resulted in a significantly better survival. Thirty-day survival has increased from 93.7% to 97.1% when treated between 2007-2011 and 2012-2016, respectively. Type of valve and valve size had no impact on survival or re-operation. Male gender, diabetes and smoking had an impact on risk of reoperation.

Conclusion: This study has shown that different factors have an impact on survival. Longer follow-up is warranted, to see if TAVR will give consistent good clinical data comparable, better or worse than SAVR.

Keywords:Age; Male gender; Diabetes; Smoking; Accessroute have an impact on long term survival