Open Access Research Article

Hemostatic Potential in Hypertension as a Basis Personificated Antitrimbothic Prevention and Therapy Technology

LY Kotlovskaya1,2, II Tyutrin3, H Kingma2,4, EV Udut5, TV Rudenko2, VP Fisenko6 and VV Udut1,2*

1Goldberg Research Institute of Pharmacology and Regenerative Medicine, National Research Tomsk State University, Russia

2Goldberg Research Institute of Pharmacology and Regenerative Medicine, National Research Tomsk State University, Russia

3Department of Anesthesiology and Resuscitation, Russia

4Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Netherlands

5Siberian State Medical University (SSMU) of Russian Ministry of Health, Russia

6First Moscow state Medical University of the Ministry of Health, Russia

Corresponding Author

Received Date: August 12, 2019;  Published Date: August 27, 2019

Abstract

The paper contains data on hemostatic potential in patients with stage 1 and stage 2 hypertension. Endothelium is a metabolic system which primarily responds to changes in homeostasis and serves as a «stabilizer» of the blood aggregate state. Hypertensive heart disease is accompanied by endothelial dysfunction manifested by vasoconstriction, increased secretion and adhesion of the hemostasis cellular system, activation of hemostasis plasma factors and, as a result, increased thrombin generation, which is the main enzyme determining the intensity of hemocoagulation. Development of endothelial dysfunction (release of the content of endothelial storage pools, contraction, and structural damage to endothelial cells with the formation of deendothelization areas and exposure of collagen fibers, etc.) contributes to the transition of hemostatic potential from hypoand normal coagulation to hypercoagulation and causes a higher risk of thrombotic complications. Therefore, are evaluation and monitoring of the hemostatic potential in therapy aimed at preventing thrombotic hemorrhagic complications great importance.

Keywords:Hemostatic potential; Endothelial dysfunction; Hypercoagulation; Antitrimbothic therapy

Abbreviations:CAC: Coefficient of Anticoagulant Activity; CS: Clot Strength; СTA: Constant Thrombin Activity; ICC: Intensity of the Coagulation Contact; ICD: Intensity of the Coagulation Drive; ICP: Intensity of the Clot Polymerization; MA: Maximum Amplitude; RICL: Retraction Intensity and Clot Lysis; RU: Relative unit

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