Open Access Review Article

Efficacy Aloe Vera in Treatment: A Literature Review

Moh Rozani1* and Kusbaryanto2

1Master of Nursing Student, Muhammadiyah University of Yogyakarta, Indonesia

2Lecturer at the Faculty of Medical Sciences, Muhammadiyah University of Yogyakarta, Indonesia

Corresponding Author

Received Date: July 01, 2019;  Published Date: July 29, 2019


Introduction: Aloe vera is a medical which has many benefits that is used in medicine to several problems in the health of human body.

Aim: Conducting a literature review study related to efficacy of aloe vera which is used for treatment in healing with body health problems.

Methods: Article searching start on date 10 – 25 August 2018 via the CINAHL database, ResearchGate, Pubmed, and ScienceDirect which is used keyword effect AND aloe vera then, selection based on inclusion criteria in the article and after getting results inclusion criteria is done critical appraisal so that relevant articles number of 9 articles.

Results: Of the 9 articles, there were 8 researching articles indicate that using aloe vera has benefits in accelerating the process of wound healing and decrease pain intensity heal burns. There is one researching article indicate date aloe vera can also be used as therapy or treatment in melasma patients with fix function skin pigment. Conclusion: Utilization of treatment using aloe vera proven to accelerate the process of wound healing and decrease some health problems of pain intensity.

Keywords:Leaf aloe vera; Efficacy; Treatment


Medical plants are the best source for getting treatment from various disease [1]. Using of natural substances with therapeutic properties has been used since ancient times (Das et al., 2011). At present, several prescribed drugs come from plants [2]. Aloe vera has been used for medical purpose in several cultures for a thousand of years Egypt, India, Mexico, Japan and China [3]. This plant has triangular leaves. Fleshy with jagged edges, yellow tubular flowers and fruits which contain a lot of seeds. Every leaf consults of 3 clear get which of containing 99% water and the other are made of glucomannan, amino acid, lipids, sterols, vitamins, and middle layers of latex which of bitter yellow sap and contains anthraquinone, glycosides, and thick out layer of is 15-20 cells referred to as peel that has a protective function, synthesize carbo hydrates and proteins. Inside the skin is a collection of blood vessels responsible to transport substances such as water (xylem) and starch (phloem) [3]. Various aloe vera extracts are mate to be easy is used in medicine to humans like gel, oil, juice, and tablets. In several researches in-vitro indicate that aloe vera leaves showed contain more than 75 nutrients and 200 active compounds, including 20 minerals, 18 amino acids and 12 vitamins. Also contain the most important components which is needed by the human body Mulu T et al. [4] Aloe vera has vitamins A, B1, B2, B6, B12, C and E. Aloe vera has a high enzyme content (for about 92 enzyme), which makes it a rare source and valuable because of enzyme help the body absorb basic nutrients at the same time purifying it and used as an antifungal, anti-inflammatory, anti-septic, can be used to accelerate the healing process of wounds [5-7]. By looking at kinds of treatment using aloe vera above, so that was done a deep literature to treatment using aloe vera in dealing with health problems.


Study researching literature that using aloe vera in treatment or therapy to overcome several health body problems.


Searching article begins of that 10-25 august 2018 by using a search strategy via the CINAHL database, Research gate, Pubmed, and ScienceDirect which is used keyword AND aloe vera and efficacy AND aloe vera and getting number of articles 4822 in all searching database. Then was checked based on the suitability of the title and abstract reading related to treatment using aloe vera and got as many as 1502 articles. Then continued the selection of articles based on inclusion criteria totaling 305 articles which can be seen in the table one. After the article was collected than a critical appraisal in using format Joanna Briggs Institute (JBI) so that of 305 critical appraisal articles the result of all relevant articles was obtained 12 articles.


Table 1: List of article criteria for doing literature review.


Table 2: Studies included in the literature review.



Learnt 9 articles found that aloe vera functional to speed up the healing process of wounds into reduce the intensity of pain in the treatment of oral lichen planus, stomatitis, diabetes mellitus, pressure ulcers, venous ulcers, chronic anal fissure, heal burns, burning mouth sydrome, alpthous minor, operation post [8]. So that could be said that the content of aloe vera has function to speed up the healing process of wounds and could reduce the intensity of pain which is due to several health body problems. There is one articles that has different to the efficacy of aloe vera, other to speed up the healing process of wounds and reduce the intensity of pain which one aloe vera gel was encapsulated in liposome was used in the healing melasma process. Because the content aloe vera gel has function as a skin pigmentation modifying agent [9]. Literature learn identified from 9 papers that have been done with critical steps so that from 9 articles discussing aloe vera which are managed or extracted in various forms and has different properties. Application in several treatment related to health problems in the forms of gel cream, juice, and solution of follows.

Aloe vera gel

Four researching articles identified the efficacy of aloe vera gel nonetheless there are differences in other of research. Ghafarzadeh M & Eatemadi A [9] using aloe vera gel extract (AGE) 0,5 % and encapsulated liposomes 1% weight of treatment given to melasma patient with significant results. Shahzad MN & Ahmed N [10] researching using aloe vera (Aloe Tone Je IR) get which is not purified and has 98% gels used for the treatment of superficial burns and partial with the result that aloe vera get can speed up the healing process of wounds and reduce the intensity of pain. López jornet P et al. [11] identify aloe vera barbadensis gel combined and tongue protector it was found that using of aloe vera gel and tongue protector can reduce duration of wound healing to burning mouth syndrome patients. Others researching’s that reduce pain score and wound size but also accelerates the healing of alpthous stomatitis wound [12].

Aloe vera cream

Three researching articles identified aloe vera which is managed into the form of cream. Researching by Babaee N et al. [12] was found using cream of aloe vera oil (AVO cream) toward wounds recovery with results with significant improvement results using pain assessment tools (VAS), AVO cream efficacy statistical test scores increased significantly (p<0.001). Rahmani N et al. [13] identified the effect of aloe vera cream 0,5% in chronic anal fissure treatment and it was found that using aloe vera cream could reduce pain and accelerate the process of wound healing during chronic anal fissure treatment. Eshghi F et al. [14] also identified the using of aloe vera cream into reduce pain and accelerate the process of post-surgery wound healing, post defection (hemorrhoidectomy) and found that aloe vera cream significantly reduced post-surgery pain at 12, 24, 48 hours and 2 weeks post-surgery and patients who is receiving aloe vera cream has decreased when take number two significantly at 24 and 48 hours after hemorrhoidectomy and aloe vera cream significantly helps wound healing to post-surgery patient during 2 weeks.

Aloe vera juice and gel

One researching has been done by Pol JS et al. [8] identified combination of aloe vera juice and gel in oral symptomatic lichen planus treatment, the said by combining treatment juice and gel in symptomatic oral lichen planus treatment reduce the duration of pain.

Aloe vera solution

Mansouri P et al. [15] using aloe vera solution to stomatitis and pain intensity in patient who undergoing chemotherapy procedures and the results were obtained that using of aloe vera solution to reduce the pain of chemotherapy to stomatitis patients are very effective with statistical test results on third day (on the 3rd day) - 14th day P : 0.001 (stomatitis intensity) and P: 0.001 (pain intensity).


Pain is common symptoms of many medical problems. Which indicates tissue damage [16]. Pain has several types such as acute pain, chronic pain, migraine, musculoskeletal, postsurgery pain, neuropathic pain, nociceptic and others [17]. One of causes of pain is wound caused by various health problems. Most researching literature reviews that discuss the using of aloe vera therapy through skin. Skin is one of organs as a protector which has function as a receiver regulate humidity, temperature modulation [18]. In 9 researching articles conducted by literature review identify ways to speed the wound healing process and reduce intensity of paint from various health problems with treatment using aloe vera. But we can the type or form of aloe vera which given in the treatment is gel, cream, solution, juice and oil which given through skin. Of 9 articles there was only one researching article which investigate treatment with using aloe vera in a type of solution in stomatitis done by gargling. Whereas it is known that one of the most effective absorption of drugs through skin is solution that aloe vera is very useful for used to wound healing process. Aloe vera gel topical using is done by application it to skin as medicine for skin conditions such as burns, psoriasis, wound and can be taken orally (through mouth) for conditions including osteoarthritis, intestinal disease, fever [19]. Pharmacological action of this get has assessed through in vitro and in vivo experiments. Preclinical researching results provide evidence that aloe vera has activity as anti-inflammatory, anti-rheumatic, anti-bacterial, and hypoglycemic [20]. Health benefits aloe vera include the application in wound healing process, treat burns and given to protection against skin damage from Aloe vera is a plan that can produce X-rays [21]. Aloe vera is a plant that can produce sap and gel. The gel is extracted from the leaves, and this is the most widely used substance as a treatment [22]. Different from traditional treatment modalities, aloe vera will great reduce medical cost intended as complementary therapy [23-25].

This paper is still limited in research using aloe vera to speed up the wound healing process and reduce intensity of pain from various health problems, in the type of gel, juice, cream, and especially solution and liquid. More researching is needed on the efficacy of aloe vera in curing various health problems.


The using of treatment that uses aloe vera has been proven to accelerate the wound healing process and reduce pain intensity in some health problems than other comparison groups and also serves as an improvement in the skin pigmentation.


We would like to thank to the lectures nursing Universitas Muhammadiyah Yogyakarta who have given support in solving this literature review.

Conflict of Interest

No conflict of interest.


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