Longitudinal follow-up Study of the Intrarenal Hemodynamics and Pulmonary Function in Patients with T2DM
Received Date: February 25, 2020; Published Date: March 10, 2020
Purpose: The main aim of this study is to long-range assess incidence of diabetic kidney disease (DKD) and pulmonary function in patients with type 2 diabetes mellitus (T2DM) during 2000 and 2015.
Methods: 60 subjects newly diagnosed with T2DM were divided into two groups according to their arterial resistivity index (RIs) (≤0.7 and >0.7). These patients underwent tests designed to assess the early changes in pulmonary function and intrarenal haemodynamics associated with diabetes, the results of which were compared to corresponding test results for the same group of patients between 2000 and 2015. The endpoints of the study were the between-group differences in the changes in the pulmonary functional parameters, the mean kidney arterial RI in the bilateral interlobular renal arteries, and the indicated renal functional parameters (BUN, Cr, AER, and UACR).
Results: The subjects with RIs ≤0.7 displayed significantly better pulmonary function in the year 2000 than subjects with RIs >0.7. Moreover, subjects in the former group displayed improvement and smaller decreases in their pulmonary functional parameters from 2000 to 2015 compared to subjects in the latter group. Additionally, subjects in the former group displayed improvement and smaller increases in their renal functional parameters, i.e., their BUN and Cr, and their AERs and UACRs from 2000 to 2015 compared to subjects in the latter group. The incidence of DKD in the group with RIs ≤0.7 (6/25, 24.00%) was significantly lower than that in the group with RIs >0.7 (23/45, 65.71%) (P<0.05).
Conclusion: The renal functional parameters, the right kidney RI may also serve as a predictor of diabetes-related changes in pulmonary function and renal injury in the future.
Keywords:Type 2 diabetes mellitus; Diabetic kidney disease; Pulmonary function; Intrarenal haemodynamics; Resistivity index
Abbrevations:Neurodegenerative disorders; Hypnosis; well-being; Embodiment; Relaxation; Complementary therapy