Elements of Prevention Against the Coronavirus and “Hypothesis of Iodine Dependent Immune Collapse in Coronavirus Micro Clots “Microvascular Covid-19 Lung Vessels Obstructive Thrombo Inflammatory Syndrome”

Prevention of Covid-19 leads us to analyze the metabolic pathways related to the virus to highlight the critical points and use simple and economic resources to fight it. The goal of Epigenetic Naturology is to provide the body with the elements it can use to defend itself. Oral cavity mucosa may be a potentially high-risk route of COVID-19 infection. ACE2 (angiotensin-converting enzyme II) receptor on the oral mucosa, which is also the receptor of SARS-CoV and HCoV-NL63, was observed to be highly expressed by the epithelial cells of the tongue [1-3], therefore oral cavity is a critical site for the study and prevention of COVID-19 infection. The iodine and/or hydrogen peroxide might be helpful in antiviral effect [3-5] in the context of COVID-19 pandemic [5,6].

A single oral dose of 130 mg potassium iodide was shown to accumulate in upper airway secretions. Since the virus also affects the eye mucosa, which is also a gateway to Covid 19, the use of Iodine povidone at 0.5- 0.6%, may enhance innate antiviral defenses [7]. Gargling with 3% hydrogen peroxide (1o vol) [8-10] 3 times a day and nebulization in the nostrils 2 times a day for 1 minute but diluted to 50% because of the nasal mucosa is more delicate, can help [11-13]. The action should be not only due to the already known oxidizing and mechanical removal properties of hydrogen peroxide correlated to the foam, but also due to the induction of the innate antiviral inflammatory response by overexpression of TLR37, thus reducing the progression of the infection from the upper to the lower respiratory tract [14]. Given the relatively low toxicity and low cost of production, a randomized controlled trial of supplemental iodide would be feasible; iodine and/or hydrogen peroxide mouthwash ang gargling could be a protective device for doctors, nurses, and people in contact with covid-19 positive patients. It is interesting the association with Melatonin, Vitamin D3, Vitamin C, Zinc, Magnesium and Potassium to support chemical reactions related to immune defense [15,16].