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Dr. Seidah obtained his BSc in 1969 from Cairo University in Egypt, and his PhD in 1973 from Georgetown University, USA. In 1974, he started studying the processing of precursor proteins at the Montreal Clinical Research Institute (IRCM), and in 1976 he co-discovered the β-endorphin and largely contributed to the biochemical characterization of the proopiomelanocortin (POMC, the β-endorphin precursor) and pro-Atrial Natriuretic factor. Since 1983, Dr Seidah is the director of Laboratory of Biochemical Neuroendocrinology. Dr. Seidah discovered and cloned seven (PC1, PC2, Furin, PC4, PC5, PACE4, PC7, SKI-1 and PCSK9) of the nine known secretory serine proteases belonging to the proprotein convertases family. During this period, he also greatly contributed to demonstrating that proteolysis by the proprotein convertases is a widely used mechanism that also affects “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. In 2003, he identified PCSK9 and showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, since PCSK9 gain-of-function mutations were linked to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor (LDLR). Dr Seidah has since worked on the elucidation of the functions and mechanisms of action of PCSK9 both in cells and in vivo, and is developing specific PCSK9 inhibitors.
Biochemical Neuroendocrinology; Health Sciences; Cardiovascular disease
Professor Dr. Alaa A. El-Dahhar is a Professor of Fish Nutrition in the Animal and Fish Production Dept. Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria. EGYPT. He is the Head of The Arabian Aquaculture Society, and the Editor – In – Chief of Journal of the Arab Aquaculture Society.He was the Vice Dean of the Faculty of Agriculture (Saba Basha) for Social Services and Environmental Affairs. He also served as a Member of the Standing Committee of Mubarak City for the upgrade of Professors and Associate Professors.Professor Dr. Alaa A. El-Dahhar was the Head of the Animal & Fish Production Department: Animal and Fish Production Dept. Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria. EGYPT. Associate Professor: (Fish Nutrition) Animal and Fish Production Dept. Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria. EGYPT. May 1994 – November, 2000. Lecturer: (Fish Nutrition) Animal and Fish Production Dept. Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria. EGYPT. September 1992 - May 1994. Visiting Scientist: (Fish Nutrition) Fisheries and Allied Aquaculture, Auburn University, Auburn, AL. USA. April, 1992 - September 1992.
Agriculture; Fish Production; Fish Nutrition
Dr. Sivanvayal Narasimhan Kishore Kumar is a Postdoctoral Research Associate at Texas A&M University College of Medicine, Department of Psychiatry and Behavioral Sciences. His research focuses on cellular and molecular mechanisms of disease, particularly autophagy, oxidative stress, iron metabolism, neuroinflammation, and neurodegeneration. He has expertise in cell and molecular biology, protein biochemistry, imaging, and transcriptomic analysis, with research contributions spanning stroke, chronic pain, Parkinson’s disease, and myocardial injury. Through his research, peer review, and collaborative scientific work, he remains committed to advancing rigorous, impactful scholarship in cell biology and biomedical research.
Psychiatry; Behavioral Sciences; Biochemistry; Glutamate receptors; Pain mechanisms
Yanying Liu is currently a professor teaching Medical Pathogenic Microbiology and Parasitology, Immunology, and Biochemistry at the Qingdao Huanghai University in China. She received her PhD in Neurobiology from the Capital Medical University (China) in 2006. In the past decade or so, she has worked as a postdoc or research staff scientist engaged in scientific research related to neuroscience at SUNY Upstate Medical University or the University of South Dakota in the USA. Dr. Liu’s research is related to several areas such as Alzheimer’s disease, Huntington’s disease, stroke, and stem cells. Her current research interests are the mechanism of the aging process, brain hypoxia, and stroke.
Aging process; brain hypoxia; stroke; stem cells
Clonal hematopoiesis; leukemia; cell immunotherapy
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