Beta Amyloid, Brain-Derived Growth Factor and Cognitive Function in Circadian Rhythm Disturbances
Received Date: February 18, 2020; Published Date: March 05, 2020
Objective: this study observes the changes of cognitive function, β-amyloid peptide (Aβ) and Brain-derived growth factor (BDNF) in circadian rhythm disturbances (CRDs).
Method: Animal models of CRDs induced by light-dark cycles in different periods. Cognitive function in mice was detected by water maze test. BDNF and Aβ levels were determined ELISA Kit.
Result:In CRDs, there were cognitive function declines, BDNF decreased and Aβ increased.
Conclusion: CRDs can lead to cognitive function declines; it was related to BDNF decreased and Aβ increased.
Keywords: circadian rhythm disturbances; cognitive function; Brain-derived growth factor; β-amyloid peptide