Open Access Research Article

Beta Amyloid, Brain-Derived Growth Factor and Cognitive Function in Circadian Rhythm Disturbances

Chang-Quan Huang*, Run-Feng Zhang, Qing-Xiu Liu, Hu Xiang, Ji Sheng Wang and Xiao-Dong Peng

Department of Geriatrics, Chongqing Medical University, China

Corresponding Author

Received Date: February 18, 2020;  Published Date: March 05, 2020


Objective: this study observes the changes of cognitive function, β-amyloid peptide (Aβ) and Brain-derived growth factor (BDNF) in circadian rhythm disturbances (CRDs).

Method: Animal models of CRDs induced by light-dark cycles in different periods. Cognitive function in mice was detected by water maze test. BDNF and Aβ levels were determined ELISA Kit.


In CRDs, there were cognitive function declines, BDNF decreased and Aβ increased.

Conclusion: CRDs can lead to cognitive function declines; it was related to BDNF decreased and Aβ increased.

Keywords: circadian rhythm disturbances; cognitive function; Brain-derived growth factor; β-amyloid peptide

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