Visual Evoked Potential in Patients with Valproic Acid Treatment
Received Date: May 09, 2019; Published Date: May 16, 2019
Purpose: The purpose of this study was to find out the safety of valproic acid use in patients with retinitis pigmentosa.
Method: 19 patients suffering from retinitis pigmentosa with using Valproic Acid as treatment were selected for the present study. Visual evoked potential was recorded for all subjects. The result obtained were compared with the control consist of 27 normal population matched with case group.
Results: The mean latency and amplitude of VEP were compared in case and control group. The mean latency/ S.D of VEP, P100 peak were 2.8/ 7.23 and 87/4.37 msec and the mean amplitude were 6 ± 1.42 and 9 ± 1.03 μv in case and control groups respectively. The difference between two groups was significant.
Conclusion: Based on the findings of present study, it can be concluded that Valproic Acid affects visual pathway which can be proved by visual evoked potential.
Keywords:Visual evoked potential; Valproic acid; Latency and amplitude of P100 peak; Retinitis pigmentosa