Intracystic Injection of Methotrexate in Postmenopausal Female Suffering from Simple Ovarian Cyst with Low Malignancy Index

Objective: To evaluate Intracystic injection of methotrexate in postmenopausal female suffering from simple ovarian cyst with low malignancy index.

Methods: Clinical randomized controlled study, two group of post-menopausal females each group had 25 patients with ovarian cyst with low malignancy index (less than 25), group I : underwent ultrasound guided aspiration of the cyst followed by methotrexate injection Group II: had no interference. Both group will be followed up for 6 months .

Results: Epidemiological data and the characteristics of the cyst at the beginning of the study showed insignificant relationship between two groups. In group I (study group) the time of the procedure was 12.15±1.035 min., with no complications. After follow up of the cases for 6 month it shows significant difference as regard recurrence / persistence of the cyst ( I case recurred in group1 ,and 15 case persist in group 2) with P value 0.000022 .While there was insignificant relationship as regard new symptoms , presence of complications and need for surgery .

Conclusion: This technique is considered a promising technique for its management, but it couldn’t be recommended by our study as this process is invasive and it shows only single advantage over expectant management.

Keywords: Post menopause; Cyst; Malignancy index; Methotrexate