Open Access Case Report

Chromosome 16 Mutations and Congenital Genitourinary Malformations

Daniel Faustin, Morgan Barlow*, Anuja Trivedi and Naila Ferris

Wyckoff Heights Medical Center, USA

Corresponding Author

Received Date: November 13, 2018;  Published Date: November 20, 2018


Posterior urethral valve (PUV) disorder is an obstructive anomaly of the genitourinary tract. Found only in males, this condition is caused by an obstructing membrane in the posterior valve of the urethra. During the early stages of embryogenesis, the most caudal end of the wolffian duct is absorbed into the primitive cloaca, forming the posterior urethral folds [1]. In fetuses with PUV, the development of these structures is arrested resulting in fusion of these primitive folds, leading to an obstruction of the outflow of urine. This pathologic finding presents on a spectrum of varying degrees, wherein the obstruction may cause only mild symptoms and present as late as early infancy or cause severe and irreversible damage during early fetal development.

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