Research Article
Assessment of the Immunomodulatory Role of Dydrogesterone in Preventing Pregnancy Loss in Threatened Abortion
Zakia M Ibrahim1, Mamdouh E Said1, Khaled M El Nahas1, Soha E Younes2, Tamer Yehia M Ali1 and Omima T Taha1*
1Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University
Omima T Taha, Lecturer of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Received Date: March 04, 2020; Published Date: March 17, 2020
Abstract
Objective: To assess the immunomodulatory role of Dydrogesterone in preventing pregnancy loss in cases of threatened abortion.
Materials and methods: This were a prospective interventional study that included two groups each included 16 women. Group 1 included 16 pregnant women presented with symptoms of threatened abortion, and group 2 that included 16 health females with normal pregnancy. All of the studied females were subjected to complete clinical assessment. Laboratory assessment of serum levels of IL-4 (Marker of T-helper 2), IFN γ (Marker of T-helper 1) and serum progesterone level were done for all participants. All women in group 1 were treated with certain doses of Dydrogesterone while women in control group were not allowed to use any form of progesterone. Participants were assessed for IL-4, IFN-γ and progesterone after treatment. Also continuing pregnancy rates were calculated.
Results: Both groups were matched as regarding patients’ characteristics and baseline parameters. Dydrogesterone has resulted in significant decrease of Th1/Th2 ratio with shift from Th1 predominance to Th2 predominance. Continuing pregnancy rate in the threatened abortion group was 93.8%.
Conclusion: Dydrogesterone is useful in the treatment of threatened abortion via modulating cytokine profile and causing shift in Th1/Th2 ratio for Th2 predominance and more specifically via decreasing level of Th1 markers as IF-γ.
Keywords: Dydrogesterone; Immunomodulation; Pregnancy; Threatened abortion
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Zakia M Ibrahim, Mamdouh E Said, Khaled M El Nahas, Soha E Younes, Tamer Yehia M Ali, Omima T Taha. Assessment of the Immunomodulatory Role of Dydrogesterone in Preventing Pregnancy Loss in Threatened Abortion. W J Gynecol Women’s Health. 3(3): 2020. WJGWH.MS.ID.000567.
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