Open Access Research Article

Assessment of the Immunomodulatory Role of Dydrogesterone in Preventing Pregnancy Loss in Threatened Abortion

Zakia M Ibrahim1, Mamdouh E Said1, Khaled M El Nahas1, Soha E Younes2, Tamer Yehia M Ali1 and Omima T Taha1*

1Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University

2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University

Corresponding Author

Received Date: March 04, 2020;  Published Date: March 17, 2020


Objective: To assess the immunomodulatory role of Dydrogesterone in preventing pregnancy loss in cases of threatened abortion.

Materials and methods: This were a prospective interventional study that included two groups each included 16 women. Group 1 included 16 pregnant women presented with symptoms of threatened abortion, and group 2 that included 16 health females with normal pregnancy. All of the studied females were subjected to complete clinical assessment. Laboratory assessment of serum levels of IL-4 (Marker of T-helper 2), IFN γ (Marker of T-helper 1) and serum progesterone level were done for all participants. All women in group 1 were treated with certain doses of Dydrogesterone while women in control group were not allowed to use any form of progesterone. Participants were assessed for IL-4, IFN-γ and progesterone after treatment. Also continuing pregnancy rates were calculated.

Results: Both groups were matched as regarding patients’ characteristics and baseline parameters. Dydrogesterone has resulted in significant decrease of Th1/Th2 ratio with shift from Th1 predominance to Th2 predominance. Continuing pregnancy rate in the threatened abortion group was 93.8%.

Conclusion: Dydrogesterone is useful in the treatment of threatened abortion via modulating cytokine profile and causing shift in Th1/Th2 ratio for Th2 predominance and more specifically via decreasing level of Th1 markers as IF-γ.

Keywords: Dydrogesterone; Immunomodulation; Pregnancy; Threatened abortion

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