Possibility of Polymicrobial Synergy and Dysbiosis of Periodonto Pathogens in the Oral Squamous Cell Carcinoma Tumour Microenvironment
School of Dentistry & Oral Health, Gold Coast Campus, Griffith University, Australia (Alumnus)
Received Date: November 10, 2020; Published Date: November 25, 2020
At least 15% of oral cancer is suspected to be associated with chronic inflammation. Hence, the role of infection associated inflammation in oral cancer gained much attention [1-3]. Recent past epidemiological evidence, facilitated the emergence of poor oral hygiene as an independent risk factor for oral squamous cell carcinoma (OSCC) [4-6]. Periodontitis is the most devastating outcome of poor oral hygiene . In several epidemiological studies, periodontitis reported to be associated with increased risk of OSCC [8-12]. Periodontitis is an inflammatory disease of the periodontium with polymicrobial aetiology . Interestingly, carcinogenic attributes of two periodontopathogenic bacteria Fusobacterium nucleatum  and Porphyromonas gingivalis  have been investigated by number of in vivo and in vitro experiments. Promising evidence has been obtained, thus inhibition of apoptosis, activation of uncontrolled cell proliferation, promotion of cell migration/ invasion as well production of carcinogenic virulence factors reported to be responsible for oral carcinogenesis . Evidently, these two periodonto pathogens have been associated with oral, pancreatic and colorectal (CRC) cancers by facilitating chronic inflammation and suppressing immuno surveillance .