Open Access Opinion

Endodontic Periapical Disease: A Virus-Based Perspective

Mohammad Sabeti1*, Kory J Golchert1, Neveed Shirgill1, Aleksandar Jakovljevic2, Miroslav Andric3 and Jelena Milasin4

1Department of Endodontics, School of Dentistry, University of California, San Francisco, USA

2Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Serbia

3Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Serbia

4Department of Human Genetics, School of Dental Medicine, University of Belgrade, Serbia

Corresponding Author

Received Date: June 29, 2019;  Published Date: July 11, 2019


There is a need for updating the current treatment modalities for periapical lesions of endodontic origin to reflect the contributions and potential morbidity from herpesvirus infection. Herpesviruses, particularly human cytomegalovirus and Epstein-Barr virus, play an important role in the symptomatic periapical lesion. Indeed, periapical lesions may remain stable and silent until they become symptomatic, possibly triggered by the activation of latent herpesviruses within the lesion itself. Given the potential for grave systemic conditions associated with herpesvirus infection, early detection and treatment decisions for periapical lesions by the dentist may positively affect a patient’s overall health; especially for the immunocompromised patient.

Keywords: Endodontic disease; Apical periodontitis; Herpesviruses; Classification

Abbreviations:RCT: Root canal treatment; HHV: Human Herpesvirus; EBV: Epstein-Barr Virus; HCMV: Human Cytomegalovirus; CBCT: Cone- Beam Computed Tomography

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