Open Access Review Article

Effects of Medications on Dental Implant Failure: A Review

Osman Babayiğit1 and Elif Öncü2*

1Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey

2Department of Periodontology, Faculty of Dentistry, Lokman Hekim University, Ankara, Turkey

Corresponding Author

Received Date: January 13, 2022;  Published Date: March 03, 2022


Several studies have shown that some commonly prescribed drugs, including bisphosphonates (BP), proton pump inhibitors (PPI), selective serotonin reuptake inhibitors (SSRI), and non-steroidal anti-inflammatory drugs (NSAID), can affect peri-implant bone healing, remodeling, and osseointegration. In order to ensure successful osseointegration of dental implants, it is important to investigate the effects of systemic diseases and regularly used medications on osseointegration. Therefore, the aim of this review is to investigate the association between the intake of medications that may affect bone metabolism and implant outcomes.

Keywords: Anti-inflammatory drugs; Bisphosphonates; Drugs-related; Implant Failure; Proton Pump Inhibitors; Selective serotonin reuptake inhibitors

Abbreviations: PPI: Proton Pump Inhibitors; SSRI: Selective serotonin reuptake inhibitors; NSAIDs: Non-steroidal anti-inflammatory drugs; BP: bisphosphonates; HR: Hazard Ratio; CI: Confidence Interval; OR: Odds Ratio

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