Allergic Reaction: Etiology, Pathogenesis with Advanced Vision in Therapeutics Modalities

Immunity is the cornerstone of the strenthening performance of the body health system. the immune system is the defense system of the body against any pathogens. Regulation of the immune system through the sympathetic and parasympathetic arms of The autonomic nervous system. Allergic reaction is an inappropriate immune response to antigen. Allergy is not a disease itself, but a mechanism leading to a disease. Allergic inflammation is a key contributor to several common diseases, including allergic asthma, allergic rhinosinusitis, atopic dermatitis and eosinophilic esophagitis, multiple sclerosis, rheumatoid arthritis, bullous pemphigoid and various types of cancer, which characterized by coordination between the innate and adaptive immune systems to promote type 2 (T2) inflammatory responses. Dietary habit and gut microbium considered the blamed factors contributing to this allergy.

Objective: to thorough the light on the correlation of daietry nutrition, gut microbiome, and intestinal immune systems, in the development of allergy.
Conclusion: There is a sort of strong association between disbiosis in gut microbium, dietiary substances and resultant inflamatory allergic disease which influence on defence mechanism of body and produce a cascede of events so modulate immune response. The cornerstone cells in this reaction IgE and mast cell, where stimulate mediators such as histamine to produce urticaria and other immune response. There is a new approach to use biological immune inhibitory therapy and antioxidant dietary nutrient to help modulate immune response.

Keywords:Immune system allergy; Anaphylaxis, Hypersensitivity reaction; IgE; Immunoglobulin; Mast cells; Innate immunity; Adaptive immunity; Dietary habits