Mini Review
Statin Intolerance: Physiology and Treatment Alternatives
Received Date: November 28, 2019; Published Date: December 04, 2019
Abstract
Despite its proven effect on primary and secondary preventions of atherosclerotic disease, statins, which revolutionized the treatment of cardiovascular diseases, are still underutilized. One of the causes of this underuse lies in the fact that some patients have some kind of intolerance to this class of medications, and this intolerance may be related to clinical symptoms of myalgia and sometimes, in a small percentage, reaching severe cases of rhabdomyolysis. The therapeutic alternatives are discussed, highlighting the use of Oriza sativa fermented by Monascus purpureus. The use of Oryza extract fermented by Monascus purpureus is an appropriate alternative for the treatment of hypercholesterolemia in patients intolerant to statins.
Keywords: Intolerance to statins; Cholesterol treatment; Monascus purpureus; Myalgia; Myositis; Myopathy; Rhabdomyolysis
