Description of the Mechanism of Positive Inotropic
Action of the Isoquinoline Alkaloid F-18

Shavkat Yu Rustamov; Inoyat Z Jumayev; Sadriddin N Boboev; Eldor B Ibragimov; Pulat B Usmanov; Mariana Georgieva Yordanova; Sherzod N Zhurakulov

Review Article

Description of the Mechanism of Positive Inotropic Action of the Isoquinoline Alkaloid F-18

Shavkat Yu Rustamov¹*, Inoyat Z Jumayev¹, Sadriddin N Boboev¹, Eldor B Ibragimov¹, Pulat B Usmanov¹ and Sherzod N Zhurakulov²

¹Institute of Biophysics and Biochemistry, National University of Uzbekistan, Uzbekistan

²Institute of Chemistry of Plant Substances, Uzbek Academy of Sciences, Uzbekistan

Corresponding Author

Received Date:May 17, 2021; Published Date:June 10, 2021

Abstract

This study evaluated the mechanism of inotropic effect of an isoquinoline alkaloid derivative, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7- dimethoxy-1,2,3,4- tetrahydroisoquinoline (F-18) using electrically stimulated rat left ventricular papillary muscle of rat. The F-18 alkaloid have been shown to have positive inotropic effect on papillary muscle contraction activity, IC50 value -14,6 μM. Са²⁺L-channel blocker - nifedipine was used in experiments. Inotropic effects of F-18 isoquinoline alkaloid on cardiomyocytes were suggested, based on results obtained in experiments carried in cardiomyocytes SR Са²⁺- transport systems modulation.

Keywords:Papillary muscle; Inotropic effect; Isoquinoline alkaloid

Article Details

Citation

Shavkat Yu Rustamov, Inoyat Z Jumayev, Sadriddin N Boboev, Eldor B Ibragimov, Pulat B Usmanov, Sherzod N Zhurakulov. Description of the Mechanism of Positive Inotropic Action of the Isoquinoline Alkaloid F-18. On J Cardio Res & Rep. 5(3): 2021. OJCRR.MS.ID.000611.

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Review Article

Description of the Mechanism of Positive Inotropic Action of the Isoquinoline Alkaloid F-18

Abstract