Therapeutic Effect of Allicin on Glioblastoma
Received Date: March 12, 2020; Published Date: April 28, 2020
Glioblastoma (GBM), as a common malignant tumor of central nervous system, is lack of effective treatments. Most of the GBM patients die in two years. Lack of effective chemotherapy is a important reason for the poor therapeutic efficacy of GBM. Several natural dietary agents have established noteworthy consideration because of their pharmacological effects. Garlic is one of the earliest cultivated plants and is commonly used as a dietary condiment worldwide. Alliin, as the most important active substance of garlic, has been proved to have diverse biologic activities including anti-inflammatory effects, antitumor effects and other effects. This article briefly reviews the therapeutic effects and mechanisms of allicin and its metabolites on GBM.
Keywords: Glioblastoma; Garlic; Alliin; Apoptosis; ROS; Histone Deacetylase