Open Access Mini Review

Sonodynamic and Photodynamic Therapy in Advanced Pancreas Carcinoma - A Case Report

Wenying Zhang1, Kun Li1, Lucy Qing Li2*, Xiaohuai Wang3, Xie Bo3 and Hong Xu2

1Oncology Department, Guangzhou Medical University of Chinese Medicine Affiliated Jinshazhou Hospital, China

2College of Engineering and Science, Victoria University, Australia

2Department of Oncology, Southern Theater, General Hospital of the People’s Liberation Army of China

Corresponding Author

Received Date: January 10, 2020;  Published Date: January 27, 2020

Abstract

Photodynamic Therapy (PDT) is a therapeutic treatment for certain kinds of tumors, approved by the FDA in 1998. Recent research data shows that a related procedure, Sonodynamic Therapy (SDT), is another new promising complementary method for cancer treatment. Here we report clinical results in an advanced pancreas cancer patient who was treated using a combination of Sonodynamic and Photodynamic Therapy (SPDT), along with conventional therapies. The patient was pathologically diagnosed with metastatic pancreas carcinoma (non-respectable advanced pancreas cancer) by the patient’s local oncology team. The advanced pancreas carcinoma had responded unsatisfactorily to conventional therapies. SPDT treatment involved using a new sensitizing agent Sonoflora a TM (SFa), which was administered sublingually; 12-hour latter, the patient was treated with a combination of light and ultrasound devices, and a low dosage of chemotherapy simultaneously as a whole body treatment (SPDT follows the chemotherapy cycle periodically). Patient had good partial responses. The results indicate that SPDT could be a promising new complementary therapeutic combination for the treatment of pancreas cancer.

Keywords: Sonodynimic therapy; Photodynamic therapy; Pancreas cancer; Chemotherapy; HIFU sensitizer; Sonosensitizer

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