Sonodynamic and Photodynamic Therapy in Advanced Pancreas Carcinoma - A Case Report

Photodynamic Therapy (PDT) is a therapeutic treatment for certain kinds of tumors, approved by the FDA in 1998. Recent research data shows that a related procedure, Sonodynamic Therapy (SDT), is another new promising complementary method for cancer treatment. Here we report clinical results in an advanced pancreas cancer patient who was treated using a combination of Sonodynamic and Photodynamic Therapy (SPDT), along with conventional therapies. The patient was pathologically diagnosed with metastatic pancreas carcinoma (non-respectable advanced pancreas cancer) by the patient’s local oncology team. The advanced pancreas carcinoma had responded unsatisfactorily to conventional therapies. SPDT treatment involved using a new sensitizing agent Sonoflora a TM (SFa), which was administered sublingually; 12-hour latter, the patient was treated with a combination of light and ultrasound devices, and a low dosage of chemotherapy simultaneously as a whole body treatment (SPDT follows the chemotherapy cycle periodically). Patient had good partial responses. The results indicate that SPDT could be a promising new complementary therapeutic combination for the treatment of pancreas cancer.

Keywords: Sonodynimic therapy; Photodynamic therapy; Pancreas cancer; Chemotherapy; HIFU sensitizer; Sonosensitizer