Open Access Research Article

Postoperative Human Papilloma Virus Positivity Rate Due to Differences in Surgical Procedures in Patients with Cervical Intraepithelial Neoplasia

Yoko To, Naoki Abe, Saya Watanabe, Sachino Kira, Sotaro Hayashi, Shigeki Fujimoto, Miho Oda, Lifa Lee, Satoshi Nishiyama, Maki Goto, Fuyuki Eguchi and Hiroshi Tsujioka*

Department of Obstetrics and Gynecology, ASO Iisuka Hospital, Japan

Corresponding Author

Received Date:September 01, 2021;  Published Date:October 11, 2021


Objective: Cervical cancer is caused by human papilloma virus (HPV) infection, and cervical intraepithelial neoplasia (CIN) is a precancerous lesion. Common treatments for CIN are conization and laser vaporization. HPV testing is useful for predicting residual or recurrent disease after surgical treatment. We performed high-risk HPV (HR-HPV) genotyping postoperatively to examine the HPV positivity rate and determine whether this rate differed depending on the surgical procedure.

Methods: This study involved 42 patients with moderate to severe CIN (CIN2/3) who showed HR-HPV positivity before surgical treatment from May 2018 to July 2019. Of the 42 patients, 24 underwent conization and 18 underwent laser vaporization. HR-HPV genotyping was performed 6 months later, and cytology was carried out every 3 to 6 months postoperatively.

Results: Thirty-nine of the 42 patients (conization, n = 22; laser vaporization, n = 17) underwent HR-HPV genotyping 6 months after the surgery and were analyzed. Eight (20.5%) of these 39 patients were HR-HPV positive. There were no cases of HR-HPV negativity with abnormal cytology. Although there was no significant difference, analysis of the postoperative rate of HR-HPV positivity by surgical procedure (conization, n = 2; laser vaporization, n = 6) showed a higher positivity rate in the laser vaporization group (p = 0.059).

Conclusion: The postoperative HR-HPV positivity rate was about 20%. Patients who underwent laser vaporization had a higher HR-HPV positivity rate than those who underwent conization.

Keywords:HR-HPV; CIN; Conization; Laser vaporization

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