Open Access Review Article

Gut Microbiome: A Potential Controller of Androgen- Modulated Disease

Shuang Liu, Luna Liu, Dandan Luo, Yu Su, Chunxiao Yu* and Qingbo Guan*

Department of Endocrinology, Shandong Clinical Medical Center of Endocrinology and Metabolism, Shandong University, China.

Corresponding Author

Received Date: January 28, 2020;  Published Date:March 11, 2021


Hypoandrogenism in males and hyperandrogenism females are both androgen disorders, which can adversely impact a variety of physiological factors. Recent studies provide that one of the principal regulators of circulating androgen is the gut microbiota. In this review, we elaborate on how gut microbial imbalance (dysbiosis) may lead to dysfunction of androgen synthesis, thereby contributing to androgen-driven disease. Some of the most common metabolic diseases namely obesity, metabolic syndrome, polycystic ovary syndrome and hypogonadism have been discussed and delineated along with recent findings. Then, suggestions for future research concerning the study are put forward as well.

Keywords:Androgen; Obesity; Gut microbiota; Complications

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