Open Access Mini Review

Edaravone’s Antioxidant Capabilities and its Therapeutic Benefits for Post-Ischemic Stroke: A Mini Review

Hunter Rolain, Gurwattan S Miranpuri and Azam S Ahmed*

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, USA.

Corresponding Author

Received Date: September 26, 2019;  Published Date: October 30, 2019


Acute-ischemic stroke (AIS) is one of the leading causes of death worldwide. IV tPA and thrombectomy have been effective in recanalizing occluded vessels. However, there is often a delay in the thrombolytic effect or completing the thrombectomy. Neuroprotective agents may bridge the gap and slow the conversion of ischemic to infarcted brain. Edaravone is a potent antioxidant capable of sequestering free radicals, reactive oxygen species (ROS) and inhibiting oxidative stress. This mini review highlights edaravone as potential antioxidant, thrombolytic adjunct, and prophylactic for cerebral edema.

Keywords: Edaravone, Tissue plasminogen activator, tPA, cerebral infarction, Amyotrophic lateral sclerosis, ALS, acute-ischemic stroke, AIS, ROS, antioxidants, neurodegenerative diseases, oxidative stress

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