Open Access Mini Review

GABA Benzodiazepine Receptors and GABA-Ergic Neurotransmission Changes in Alcohol and Nicotine Dependency

Behzad Saberi and Behrouz Saberi Tehrani*

1MD, PhD

2Specialist in Preventive and Community Medicine, Iran

Corresponding Author

Received Date: February 22, 2019;  Published Date: March 06, 2019


GABA-A receptors have an important role in modulation of the effects of ethanol in the brain. GABA receptors as ion channels which are basically ligand gated ones, modulate the inhibitory synaptic transmission in the central nervous system. Alcohol addiction phases such as withdrawal, dependency and tolerance are associated with the GABA-ergic neurotransmission changes in the brain [1,2]. The neuroimaging studies with PET and SPECT have demonstrated that there are lower GABA-A benzodiazepine receptors availability in alcohol dependent subjects.

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