Conformational Studies on (+)-epi-goniofufrone
and Hirsutic Acid Reveals Patterns of Conformer
Populations in Triquinane Sesquiterpenes

Sahar Sakhaee; Mohammad Hossein Sakhaee; Saghar Sakhaee; Ahmad Takallou; Akbar Mobaraki; Nader Sakhaee; Nader Sakhaee

Research Article

Conformational Studies on (+)-epi-goniofufrone and Hirsutic Acid Reveals Patterns of Conformer Populations in Triquinane Sesquiterpenes

Sahar Sakhaee¹, Mohammad Hossein Sakhaee², Saghar Sakhaee³, Ahmad Takallou⁴, Akbar Mobarakⁱ⁵ and Nader Sakhaee^6,7*

¹Islamic Azad University, Iran

²Mashhad University of Medical Sciences, Iran

³Medical University of Shahrood, Iran

⁴Department of Chemistry, Kharazmi University, Iran

⁵Department of Chemistry, Tarbiat Modarres University, Iran

⁶Department of Mathematics and Natural Sciences, Harris Stowe State University, USA

⁷Department of Chemistry, Southern Illinois University Edwardsville, USA

Corresponding Author

Received Date: October 24, 2019; Published Date: October 30, 2019

Abstract

Cyclic compounds are frequently found in natural products, prevailing specially in alkaloids. Whether the choice of nature for these carbonic skeletal frameworks, is conformationally beneficial, has yet to be explored. In this paper we try to show how nature’s choice of cyclic carbonic framework in two triquinane sesquiterpenes is responsible for populating specific conformers to provide bioactivity. Conformational analysis of cisoctahydropentalenes can provide a telltale sign that conformational preference may be a predesigned aspect of both (+)-epi goniofufrone and hirsutic acid. conformational analyses are done, using ωb97xd/6-311+G(d) level of theory. The model was then tested to analyze the stable conformers in, (+)-epi-goniofufrone and hirsutic acid, respectively. The results are in line with our previous findings on chondrosterin J, and further work is underway to find a comprehensive detailed conformational landscape for fused five membered rings.

Keywords: Bioactive conformers; Cis-octahydropentalene; (+)-epi-goniofufrone<; Hirsutic acid; Triquinane sesquiterpenes

Article Details

Citation

Nader Sakhaee, Sahar Sakhaee, Mohammad Hossein Sakhaee, Saghar Sakhaee, Ahmad Takallou, Akbar Mobaraki. Conformational Studies on (+)-epi-goniofufrone and Hirsutic Acid Reveals Patterns of Conformer Populations in Triquinane Sesquiterpenes. Insi in Org & Inorg. 1(1): 2019. IOIC.MS.ID.000501.