A Sensıtıve and Sımple Spectrofluorımetric Method for
Analysıs Antı-Hypertensıve Drugs in Pharmaceutıcal
Preparatıons

A Hakan AKTAŞ; Tuğçe PEKUZ

Research Article

A Sensıtıve and Sımple Spectrofluorımetric Method for Analysıs Antı-Hypertensıve Drugs in Pharmaceutıcal Preparatıons

A Hakan AKTAŞ* and Tuğçe PEKUZ

Süleyman Demirel University, Department of Chemistry, Turkey

Corresponding Author

Received Date: January 24, 2020; Published Date: January 29, 2020

Abstract

This work describes a simple, sensitive and reliable spectrofluorimetric method for the simultaneous determination of two anti-hypertensive drugs; benazepril. HCl (BEN) and hydrochlorothiazide (HCT) in their combined tablets. The method involved measurement of the native fluorescence at 389 nm (λEx 358 nm) and 389 nm (λEx 360 nm) for BEN and HCT respectively. Analytical performance of the proposed spectrofluorimetric procedure was statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, detection and quantification limits. Regression analysis showed good correlation between fluorescence intensity and concentration over the concentration ranges 1.0-5.0 and 1.25-6.25 μg mL^-1 for BEN and HCT, respectively. No interference was observed from common pharmaceutical additives. .

Keywords: Benazepril HCl; Hydrochlorothiazide; Spectrofuorimetry

Article Details

Citation

A Hakan AKTAŞ, Tuğçe PEKUZ. A Sensıtıve and Sımple Spectrofluorımetric Method for Analysıs Antı-Hypertensıve Drugs in Pharmaceutıcal Preparatıons. Insi in Org & Inorg. 1(1): 2020. IOIC.MS.ID.000504.