Open Access Mini Review

A Long Non-coding RNA and its Potential Role in Human Myeloid Leukemia

David Reisman*

Department of Biological Sciences, University of South Carolina Columbia, USA

Corresponding Author

Received Date: February 23, 2021;  Published Date: March 08, 2021

Abstract

Over the past ten to fifteen, lncRNAs have been discovered to be expressed widely in eukaryotes and function as regulators of many diverse biological processes. We have identified a novel long non-coding RNA (lncRNA) that, as our early evidence indicates, participates in maintaining the undifferentiated and proliferative state of human myeloid leukemia-derived cells. With the accumulating evidence that lncRNAs act in regulating genes required for proper cell differentiation, the enhanced expression of the lncRNA we identified in myeloid leukemias and its apparent role in maintaining the proliferative state of these cells is quite significant, both in terms of understanding lncRNA function, and the potential design of novel therapeutics for myeloid leukemias.

Keywords: Long noncoding RNA; Leukemia; Differentiation

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