Karima Abbaci Daghor1,2*, Amel Otmane2, Mohamed Makrelouf2, Karima Belatar2, Nadia Ait Hamadouche3,
Chafia Dahou-Makhloufi4, Farida Mechid4 , Fifi Otmani5, Zohra Lerari5, Chafika Haouichet6, Fella Hanni7,
Salima Lefkir Taffiani8, Bilel Bengana8, Nacera Benfenatki9, Smail Nourredine10, Rafika Bougherarou11,
Mounir Tabouche11, Fatma Zohra Aissat12, Nadia Boukheris13, Amar Tebaibia14, Baya Taharbouchet15,
Soraya Ayoub16, Brahim Benziane17, Nadia Oumnia18, Djennete Hakem19, Malika Boucelma20, Nazim
Laraba1 and Abdelkrim Berrah1
1Department of Internal medicine, Bab El Oued University Hospital center, University of Algiers 1, Faculty of Medical sciences, Benyoucef Benkhedda, Algeria,
North Africa
2Department of Biochemistry, Hemotology and genetics laboratory of research, Algeria, North Africa
3Department of Epidemiology, Bab El Oued University Hospital center, Algeria, North Africa
4Department of Rheumatology, Bab El Oued University Hospital center, Algeria, North Africa
5Department of Internal medicine, Mustapha Bacha University Hospital center, Algeria, North Africa
6Department of Rheumatology, Douera University Hospital center, Algeria, North Africa
7Department of Rheumatology, Benaknoun University Hospital center, Algeria, North Africa
8Department of Rheumatology, Benimessous University Hospital center, Algeria, North Africa
9Department of Internal medicine, Rouiba University Hospital center, Algeria, North Africa
10Department of Epidemiology, Mustapha Bacha University Hospital center, Algeria, North Africa
11Department of Radiology, Bab El Oued University Hospital center, Algeria, North Africa
12Department of Infectious diseases, El Hadi Flici University Hospital centre, Algeria, North Africa
13Department of Internal medicine, Annaba University Hospital centre, Algeria, North Africa
14Department of Internal medicine, Birtraria University Hospital centre, Algeria, North Africa
15Department of Internal medicine, Bouloughine University Hospital centre, Algeria, North Africa
16Department of Internal medicine, Benimessous University Hospital centre, Algeria, North Africa
17Department of Internal medicine, Laghouat University Hospital centre, Algeria, North Africa
18Department of Internal medicine, Zmirli University Hospital centre, Algeria, North Africa
19Department of Internal medicine, Mostaghanem University Hospital centre, Algeria, North Africa
20Department of Internal medicine, Kouba University Hospital centre, Algeria, North Africa
Corresponding Author
Karima Abbaci Daghor, Department of Internal medicine,
Bab El Oued University Hospital center, University of Algiers 1, Faculty of Medical
sciences, Benyoucef Benkhedda, Algeria, North Africa.
Abstract
Background: The severity of Adult Onset Still’s Disease (AOSD) can be attributed to its life-threatening complications with organ damage, the
chronic course with high rate of relapses and the occurrence of erosive arthritis.
Objective: To identify the prognostic factors in AOSD
Methods: We conducted a multicenter prospective longitudinal nationwide study in tertiary rheumatology and Internal Medicine departments
(16 departments) to enroll successively patients with established AOSD diagnosis who fulfilled either Yamaguchi or Fautrel criteria with the
exclusion of any cause that can explain the clinical picture. All clinical and biological data were collected in a consensual and standardized clinical
assessment at baseline and during follow up. The different clinical and biological features at diagnosis were compared to the clinical course and the
complications of AOSD.
Results: 80 patients with AOSD were included. Life-threatening complications with organ damage occurred in 11 patients who presented 14
complications. 56 (70 %) patients had a chronic course with 23.7% erosive arthritis. A third of patients relapsed at 3 months, 6 months and 12
months. Low Glycosylated Ferritin (GF≤ 10%) is a predictive factor of life threatening complications (p= 0.001), corticosteroid dependence and early
relapses at 3 months (p=0.02). Prognostic factors of erosive arthritis are polyarthritis (p=0.006), chronic course (p=0.02) and relapses at 6 months
(p=0.02).
Conclusion: Lower glycosylated Ferritin (GF≤ 10%) was predictive of life-threatening complications, corticosteroid dependence and high rate
of relapses in Adult Onset Still’s Disease. Polyarthritis, chronic course and high rate of relapses were predictive of erosive arthritis.
Keywords: Adult Onset Still’s Disease; Prognostic Factor; Glycosylated Ferritin; Polyarthritis; Chronic course; Relapses; Erosive arthritis
Research Article
