Open Access Short Communication

Decreased Joint Pain Associated with Curcumin Use in a Controlled Study for Alzheimer’s Disease: A Serendipitous Observation

John M Ringman1, Greg M Cole1,2 and Sally Frautschy*1,2

1Department of Neurology, Mary S Easton Center for Alzheimer’s Disease Research, USA

2Department of Neurology, Geriatric Research Education and Clinical Center, USA

Corresponding Author

Received Date: January 06, 2020;  Published Date: January 21, 2020


Curcumin is a natural product with anti-inflammatory properties for which there is preliminary evidence of efficacy in the treatment of arthritis. We performed a 24-week, randomized, placebo-controlled, and blinded study of curcumin for Alzheimer’s disease in which there was a 24-week open-label extension. At each visit, subjects and their informants were specifically queried about adverse events with a comprehensive checklist that included the presence or absence of joint pain. We serendipitously found a dose-dependent trend for decreased reports of joint pain. This observation provides evidence for the efficacy of curcumin for the treatment of joint pain in the elderly.

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