Open Access Case Report

Behind the Scenes Of Cns Vasculitis: A Rare Case of Cns Vasculitis with Two Primary Malignancies

Savvina Prapiadou1, Daniel Woo2, Adam Koss2, Andrew Creed2, Rina Mina3, Priyanka Vashisht3, Kristina Brannock4, Mosaab Mohameden3*

1Department of Medicine, University of Patras College of Medicine, Greece

2Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, USA

3Department of Internal Medicine, Rheumatology Division, University of Cincinnati College of Medicine, USA

4Department of Pathology, University of Cincinnati College of Medicine, USA

Corresponding Author

Received Date: July 09, 2021;  Published Date: October 05, 2021


To highlight the importance of a broad differential diagnosis, including malignancy, in patients with central nervous system vasculitis (CNSV) presenting as multiple, recurrent cryptogenic strokes.

Recent Findings

We describe a rare entity, CNSV in the setting of two underlying neoplastic disorders and a chorioretinal inflammatory disease. The clinical presentation, imaging study results, histopathologic features, and response to treatment are reported.


Cancer-associated CNSV is a rare cause of recurrent cryptogenic strokes. This case highlights the importance of clinical suspicion of and comprehensive work-up for neoplasms in a patient presenting with brain lesions consistent with CNSV.

Keywords: Vasculitis; Infarction; Visual loss; Retina; Paraneoplastic syndrome


APMPPE- Acute posterior multifocal placoid pigment epitheliopathy

CNSV- Central Nervous system Vasculitis

MRI- magnetic resonance imaging

MRA- magnetic resonance angiography

ANA- anti-nuclear antibody

CSF- Cerebrospinal fluid

PET- positron emission tomography

CT - computerized tomography

CYC- cyclophosphamide

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