Open Access Mini Review

Anxiolytic and Analgesic Effect Plant in Arthritis Disease

Atsang à Kiki Gisèle*

Department of Biology Sciences, University of Maroua, Cameroon

Corresponding Author

Received Date:September 28, 2021;  Published Date: October 19,2021


55% of patients with chronic pain have anxiety disorders, contributing reduced quality of life. Although pain and anxiety appear to be co-occurring, an analgesic or an anxiolytic compound used alone is often ineffective to reduce all symptoms. The combination therapy induces severe additive effects likes’ nausea, vomiting, diarrhea. For these reasons, the development of analgesic compounds with anxiolytic properties could prove very advantageous for the treatment of chronic pain like arthritis.


Inflammation represents a process designed to combat infection or tissue injury. It is a physiological response of a body to stimuli, including infections and tissue injury, and protects the body from these inflammatory stimuli [1]. The complex events and mediators involved in the inflammatory reaction can induce, maintain or aggravate many pathological conditions, such as bacterial sepsis, rheumatoid arthritis and skin inflammation [1]. In fact, most human diseases are associated with pain and inflammation component. That is why analgesic and anti-inflammatory drugs are among the most prescribed drugs in clinical practice [1]. Analgesic drugs act in various ways on the peripheral and central nervous systems. When choosing analgesics, the severity and response to other medication determines the choice of agent; the World Health Organization (WHO) pain ladder [2]. Analgesic choice is also determined by the type of pain: For neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants [3].


An anxiolytic (also antipanic or antianxiety agent) (Dorland’s Medical Dictionary) is a medication, or other intervention, that inhibits anxiety. This effect is in contrast to anxiogenic agents, which increase anxiety. Together these categories of psychoactive compounds or interventions may be referred to as anxiotropic compounds or agents. Some recreational drugs such as alcohol induce anxiolysis initially; however, studies show that many of these drugs are anxiogenic. Anxiolytic medications have been used for the treatment of anxiety disorder and its related psychological and physical symptoms. Light therapy and other interventions have also been found to have an anxiolytic effect [4].


Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder usually affecting the symmetrical bilateral joints [5]. Uncontrolled RA characterized by progressive damages of synovial, cartilage, and bone is associated, probably, with extra-articular signs [6, 7]. RA may possibly progress to severe disability with direct negative impacts on lifestyle and increase in mortality rate [8,9]. The overall prevalence of clinically diagnosed RA was 0.5–2% of the population with higher prevalence in developed countries.

Relationship between pain and anxiolytic

Despite the progress made in medical research during the past decades, the treatment of many chronic diseases is still problematic. Inflammatory diseases remain among others one of the world’s major health problems [10]. The activation of the Hypothalamous axis will ensure to provide the necessary energy substrate Support Citation: Atsang à Kiki Gisèle. Anxiolytic and Analgesic Effect Plant in Arthritis Disease. Arch Phar & Pharmacol Res. 2(5): 2021. APPR. MS.ID.000550. DOI: 10.33552/APPR.2021.02.000550. Page 2 of 2 the sympathetic response and participate in cognitive, behavioral and endocrine adaptation to the painful stressful situation [11]. This adaptive response of the HHS axis observed in acute pain (acute stress) could potentially be altered when this pain is continuous and extends over time to ultimately have an adverse effect on the body (Blackburn-Munro and Blackburn-Munro, 2001).


We hope that the analgesic will have the same effects as the reference anxiolytics used.



Conflict of Interest



  1. Atsang AKG, Dzeufiet DPD, Foyet HS, Dimo T, Kamtchouing P (2014) Analgesic and Anti-inflammatory Effect of the Aqueous Extract of Dichrostachys glomerata (Forssk.) Hutch Fruits. European Journal of Medicinal Plants 4: 964-978.
  2. Anonymous (1990) Cancer pain relief and palliative care; report of a WHO expert committee. World Health Organization Technical Report Series, 804. Geneva, Switzerland: World Health Organization pp. 1-75.
  3. Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, et al. (2003) "Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations". Archives of Neurology 60: 1524-1534.
  4. Youngstedt, Shawn D, Kripke Daniel F (2007) "Does bright light have an anxiolytic effect? – an open trial". BMC Psychiatry. 7: 62.
  5. Rajaram C, Reddy KR, Chandra KB (2015) Evaluation of anti-arthritic activity of Caesalpinia pulcherrima in freund's complete adjuvant induced arthritic rat model. J Young Pharm 7: 128-132.
  6. Shi F, Zhou D, Ji Z, Xu Z, Yang H (2015) Anti-arthritic activity of luteolin in Freund's complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway. Chem Biol Interact 226: 82-87.
  7. Bhalekar MR, Upadhaya PG, Nalawade SD, Madgulkar AR, Kshirsagar SJ (2015) Anti-rheumatic activity of chloroquine-SLN gel on wistar rats using complete freund's adjuvant (CFA) model. Indian J Rheumatol 10: 58-64.
  8. Gomes RP, Bressan E, Silva TM, Gevaerd SM, Tonussi CR, et al. (2013) Standardization of an experimental model suitable for studies on the effect of exercise on arthritis. Einstein (São Paulo) 11: 76-82.
  9. Kapetanovic M, Lindqvist E, Geborek P, Saxne T, Eberhard K (2011) Long-term mortality rate in rheumatoid arthritis patients with disease onset in the 1980s. Scand J Rheumatol 40: 433-438.
  10. Adedapo AA, Sofidiya MO, Afolayan AJ (2009) Anti-inflammatory and analgesic activities of the aqueous 275 antianxiety agent" at Dorland's Medical Dictionary. J. Phys. Pharm. Adv 2(8): 269-276
  11. Sapolsky RM, Romero LM, Munck AU (2000) "How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions." Endocr Rev 21(1): 55-89.
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