Research Article
The Protective Effect of Curcumin Against Cisplatin- Induced Nephrotoxicity Experimentally in Rats
Abd Alkareem Omar Maghmomeh2*, Noha Abdel Rahman1 and Amal Mohamed El Gayar 1
1Department of Biochemistry, University of Mansoura, Egypt
2Department of Biochemistry, Delta University for Science and Technology, Egypt
Abd Alkareem Omar Maghmomeh, Department of Biochemistry, Faculty of Pharmacy, Delta University for science and technology, International Coastal Road, Gamasa city, Mansoura 35712, Egypt.
Received Date:November 20, 2019; Published Date: December 12, 2019
Abstract
The incidence of acute kidney injury (AKI) has been increasing over time. AKI increase the risk of progression of chronic kidney disease. Acute and chronic renal failures are global public health issues with different features to take into account in different parts of the world. Curcumin has renal protective properties against kidney damage. The exact mechanism of such protection is not clear. Therefore, this study was conducted to examine the molecular levels of the protective effect of curcumin on cisplatin induced nephrotoxicity in rats. We investigated the effects of curcumin in AKI which was induced in male Sprague Dawley rats using cisplatin (4.5 mg/ kg in 2 consecutive days). Curcumin was administered by oral tubes 200mg/kg daily for 21 days. Serum creatinine, creatinine clearance, urea nitrogen, oxidative stress markers [glutathione (GSH), lipid peroxide (Malondialdehyde)] assessments of these parameters were carried out to indicate the effect of curcumin in AKI. Serum analysis revealed an alteration in parameters of kidney. A decrease in the antioxidant activity of kidney was recorded in cisplatin group while curcumin administration restored it. The results clarified the strong protective effect of curcumin on cisplatin induced nephrotoxicity in rats at the molecular levels.
Keywords: Acute kidney injury; Oxidative stress; Curcumin
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Abd Alkareem Omar Maghmomeh, Noha Abdel Rahman, Amal Mohamed El Gayar. The Protective Effect of Curcumin Against Cisplatin-Induced Nephrotoxicity Experimentally in Rats. Arch Phar & Pharmacol Res. 2(4): 2019. APPR.MS.ID.000542.