The Benefit of Acetyl-L-Carnitine in Chemotherapy Induced Peripheral Neuropathy: A Systematic Review

Chemotherapy induced peripheral neuropathy (CIPN) is the most common neurological syndrome secondary to antineoplastic therapy. The CIPN primarily affecting patients being treated with taxanes and platinum derivatives. The most common complain is sensory neuropathy. The available treatment for neuropathic pain are not come from chemotherapy induced peripheral neuropathy sub group population. The existing treatment is only symptom control and can not prevent further damage of the nerve. This study aimed to perform systematic review of the literature on the benefit of Acetyl L Carnitin (ALC) for chemotherapy induced peripheral neuropathy. The ALC is believed to increase the Nerve Growth Factor (NGF) that play important role in nerve health. Recent studies have shown that ALC is promising. The statement come from low quality evidences. Further studies with more valid approach are warranted.

Keywords: Chemotherapy induced peripheral neuropathy; ALC; Systematic review; RCT