Research Article
Novel Cocrystals of Glipizide: Green Supramolecular Mechanosynthesis
Dimpy Rani1, Sarb Sukhmani Kaur Dargan2, Parnika Goyal2 and Renu Chadha2*
1G D Goenka University, Gurgaon-122103, India
2University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
Renu Chadha, Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
Received Date:October 26, 2018; Published Date: November 13, 2018
Abstract
The present research demonstrates the five novel cocrystals of glipizide (GPZ) with picolinic acid (PA), adipic acid (AA), isonicotinic acid (INA), fumaric acid (FA) and sorbic acid (SRA). The cocrystals were prepared via green supramolecular mechanosynthesis approach and exhibited 1:1 stoichiometric ratio. The cocrystals were characterized by thermal (DSC) and spectroscopic (PXRD, FTIR and SSNMR) techniques. PXRD data was used to elucidate the crystal structure. GPZ-PA, GPZ-AA, GPZ-INA, GPZ-FA and GPZ-SRA were found to be crystallized in triclinic and monoclinic crystal systems, which exist in P-1, P1 and P21 space groups. Remarkable improvement in solubility and intrinsic dissolution rate (IDR) was observed along with significant reduction in rat blood serum glucose level and high Cmax in comparison to GPZ.
Keywords:Glipizide; Cocrystals; Crystal structure; Solubility; Pharmacological studies
Abbrevations:GPZ: Glipizide; PA: Picolinic Acid; AA: Adipic Acid; INA: Isonicotinic Acid; FA: Fumaric Acid; SRA: Sorbic Acid; API: Active Pharmaceutical Ingredients; GRAS: Generally Regarded as Safe; LAG: Liquid Assisted Grinding; DSC: Differential Scanning Calorimeter; PXRD: Powder X-ray Diffraction; FTIR: Fourier Transform Infrared; SSNMR: Solid State Nuclear Magnetic Rasonance
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Renu Chadh, Dimpy Rani, Sarb Sukhmani Kaur Dargan, Parnika Goyal. Novel Cocrystals of Glipizide: Green Supramolecular Mechanosynthesis. Arch Phar & Pharmacol Res. 1(3): 2018. APPR.MS.ID.000511.