Case Report
Metronomic Chemotherapy in Selected Children with Refractory Tumors; Report of Four Cases and a Review of the Literature
Mahdi Shahriari1 and Babak Abdolkarimi2*
1Department of Pediatric Hematology Oncology, Shiraz University of Medical Sciences, Iran
2Department of Pediatric Hematology Oncology, Lorestan university of Medical Sciences, Iran
Babak Abdolkarimi, Asistant professor of pediatric hematology oncology. Lorestan university of Medical Sciences, khorramabad, Iran.
Received Date:May 25, 2019; Published Date: May 30, 2019
Abstract
Metronomic chemotherapy is the continual, systemic administration of non-toxic chemotherapy doses that target proliferating endothelial cells during tumor angiogenesis [1]. This strategy began 40 years ago in adult oncology, but there is few experiences in pediatric settings [2]. After a systematic review on evidence-based documents and selection of metronomic chemotherapy protocols from the literature; eligible patients were received this kind of chemotherapy after informed consent taken from their parents.
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Mahdi Shahriari, Babak Abdolkarimi. Metronomic Chemotherapy in Selected Children with Refractory Tumors; Report of Four Cases and a Review of the Literature. Arch Phar & Pharmacol Res. 1(4): 2019. APPR.MS.ID.000519.