Adjustable Quarto Stimuli (T, pH, Redox, Hyperthermia) Targeted Nanocontainers (Nano4Dox and Nano4Cis) for Cancer Therapy Based on Trojan Horse Approach

We developed a quadrupole stimuli responsive targeted nanomedicine platform with the key goal to provide a solution to the outstanding problem “How can the delivered therapeutic dose to the tumour be increased while at the same time reducing the dose in healthy tissue?” When accomplishing this goal, we will offer a huge improvement in the length and quality of life of cancer patients. Our preliminary animal study give hope in that course. We attempted to accomplish this goal via an innovative and patented therapeutic approach based on novel polymeric nanocarriers (NCs), which enables targeted drug delivery in tumors. The in-vivo results suggest that both Nano4Dox and Nano4Cis platforms outperforms the commercial standards like Doxil® and Lipoplatin, respectively. These platforms offer a significant business opportunity besides the therapeutic value offering to millions of people hope for better life and cure.