<SUP>13</SUP>C Solid State Nuclear Magnetic Resonance as a Tool
for Studying Polymorphism in Pharmaceuticals

Eduardo Gomes Rodrigues de Sousa; Rosane Aguiar da Silva San Gil

Mini Review

¹³C Solid State Nuclear Magnetic Resonance as a Tool for Studying Polymorphism in Pharmaceuticals

Eduardo Gomes Rodrigues de Sousa¹ and Rosane Aguiar da Silva San Gil^2,3*

¹Fundação Oswaldo Cruz, FIOCRUZ/Instituto de Tecnologia em Fármacos, Brazil

²Universidade Federal do Rio de Janeiro, Instituto de Química, Brazil

³Universidade Federal do Rio de Janeiro, Instituto de Pesquisas de Produtos Naturais, Brazil

Corresponding Author

Received Date:December 09, 2019; Published Date: December 19, 2019

Abstract

The predisposition of pharmaceutical solids to crystallize in various forms can lead to differences in their physical and chemical properties. The study of polymorphism is an important step in drug development because it causes a relevant physical and chemical characteristic in both the API and the formulated drug. NMR is one of the most versatile techniques for structural characterization. In addition, Solid State NMR is important for the study of organic and inorganic compounds, both for structural determination and for the use of samples, bonding types and geometry, as well as for analytical studies and their applications in a wide range of areas, including drug studies, such as pure API or pharmaceutical formulations and excipients. In this mini review, there are some examples about its use for studying polymorphism in pharmaceuticals.

Keywords: Solid state NMR; ¹³C CPMAS; Polymorphism; Pharmaceuticals

Article Details

Citation

Rosane Aguiar da Silva San Gil, Eduardo Gomes Rodrigues da Sousa. 13C Solid State Nuclear Magnetic Resonance as a Tool for Studying Polymorphism in Pharmaceuticals. Arch Phar & Pharmacol Res. 2(4): 2019. APPR.MS.ID.000543.

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