Some Clinical, Psychological, Laboratory, and Genetic Aspects of Patients with Multiple Sclerosis in Upper Egypt
Received Date: June 21,2021; Published Date: July 21, 2021
Aim: Multiple sclerosis is the most prevalent chronic inflammatory disease of the central nervous system. The aim of the study is to show some clinical, cognitive, labarotory and genetic aspects in patients with multiple sclerosis in Upper Egypt.
Materials & Methods: 40 patients with MS recruited along the period from Jan.1st 2017 to Dec.31st2017 and 40 healthy controls were included in the study. Clinical, cognitive (depression, anxiety, and sleep), laboratory (25-hydroxyvitamin D), and genetic (TMEM106B, APOE2, and APOE1) aspcts were assessed.
Results and conclusion: Low serum 25(OH) D level is a major risk factor for MS in Upper Egypt. Vitamin D deficiency increases the risk of developing depression in MS patients. APOE1, APOE2 polymorphism alone, does not affect MS susceptibility.