Relative ESR1 Gene Expression in Major Depression a Biomarker for Hormone Therapy

Depression is a common disease which emerges with a disorder in temper. It results from environmental genetically and physiological factors. One of the effective factors can be the change in hormones and disorder in their intake through cells. In way that one can explain these hypotheses with post-pregnancy depression. The present study aimed to compare estrogen receptor1 gene expression in patients with major depression and healthy individuals. The study used causal-comparative method. For this study, 17 patients who suffered major depression referred to the clinic and 30 healthy subjects were randomly selected. After taking blood samples, estrogen receptor1 gene expression was carried out using Real Time PCR. The results showed that the expression of ESR1 gene was significantly reduced in patients with major depression (P value < 0.05). This result showed that ESR1 gene can be used as a genetically marker for major depression. Also, stimulating estrogen receptor 1 or raising the estrogen level of blood can be applied to reduce depression signs.

Keywords: ESR1 gene expression; Hormone change; Hormone therapy; Major depression; Real time PCR; Stimulating estrogen receptor