Peptide Upregulation and Inflammatory Cascading:
The Downstrea Outcome of Autonomic Dysregulation

Samah Khaled Zahran

Review Article

Peptide Upregulation and Inflammatory Cascading: The Downstrea Outcome of Autonomic Dysregulation

Peter Behel*

Department of Psychology, Sonoma State University, USA

Corresponding Author

Received Date: April 13, 2023; Published Date: May 08, 2023

Abstract

Peptide upregulation is an essential component of the pain signal transmission process known as nociception. During nociception the body’s principle excitatory neurotransmitter glutamate is co-released with the neuropeptide substance P to relay pain signals from the periphery to the central nervous system. Various studies have determined that the autonomic nervous system exerts a stimulating effect on substance P, and the extent to which substance P plays a primary role in pain signal conduction underscores the influence that autonomic functioning has on nociception itself. Insofar as the release of substance P is responsible for producing an extended inflammatory profile, hyperactive sympathetic nervous system functioning represents a largely unaccounted for mechanism involved in perpetuating inflammatory cascading.

Article Details

Citation

Peter Behel*. Peptide Upregulation and Inflammatory Cascading: The Unseen Outcome of Autonomic Dysregulation. Arch Neurol & Neurosci. 15(2): 2023. ANN.MS.ID.000859.