Open Access Review Article

Long Non-Coding RNAs in Spinal Cord Injury

Rajan Jayanth1, Jean-Jacques Michaille2,3, Alexander A Efanov1, Hamdy Awad1 and Esmerina Tili1,3*

1 Department of Anesthesiology, The Ohio State University, USA

2 Université de Bourgogne-Franche Comté, France

3 Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Centre and Comprehensive Cancer Centre, USA

Corresponding Author

Received Date: January 20, 2020;  Published Date: January 30, 2020


Introduction:: The current study aimed to develop an easy approach to the different neuromuscular disorders causing hand weakness.

Methods: 81 patients suffering from unilateral or bilateral hand weakness were subjected to neurological examination and electrophysiological assessment and imaging of the cervical cord by Magnetic resonance image for patients with mixed upper and lower motor neuron lesion.

Results:Inflammatory disorders were [24]; demyelinating neuropathy (5), axonal neuropathy (17), polymyositis (1) and myasthenic myopathy (1). Compressive disorders were [22]; median entrapment (11), radial and ulnar entrapment (5), degenerative radiculopathy, myelopathy (3), cervical syringomyelia (1) and thoracic outlet syndrome (1). Motor neuron disease (17). Hereditary disorders were [12]; myotonia (7), myopathy (2) and hereditary neuropathy (3). Traumatic disorders were [6]; radial and ulnar injury (4) and brachial plexus injury (2).

Discussion:We concluded that; inflammatory disorders were the most frequent causes of hand weakness. An algorithmic approach of hand weakness was concluded.

Keywords:Hand weakness; Neurophysiology; Neuropathy; Myopathy; Myasthenia; Diagnostic approach

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