Location of Glioblastoma and its Significance in Response to Treatment

Recent years have seen progression in the understanding of the pathogenesis, epigenetic and genetic changes in glioblastoma (GB). These characterizations have focused mainly on the prognostic significance and potential targets for therapeutic intervention. However, other traits of these highly malignant tumors have also been discovered as biproducts or as primary areas of research. Both surgery and radiation are less effective in periventricular glioblastoma, perhaps owing to this area being the niche for pluripotent stem cells in glioblastoma. Surgery carries less of a survival benefit in deep seated glioblastoma, in part because gross total resection of these tumors is uncommonly reached. All treatment modalities are less efficacious for multifocal glioblastoma. There is not enough data in the literature about the prognosis and treatment of specific single lobe supratentorial glioblastoma.