Antitumor Activity of Novel Azoles on Ehrlich Ascites Carcinoma Cells in Mice

Background: Azoles has been used traditionally for many centuries. Some impressive therapeutic qualities have been discovered.

Aim: Our study aims to investigate in vivo antitumor, and antioxidant activities of Ethanolic Azoles. Also, to study the side effects of Azoles on different organs (Liver/ Kidney).

Materials & Methods: We assessed the effect of Azoles on life span prolongation and on the levels of malondialdehyde (MDA), nitric oxide (NO), Catalase, glutathione peroxidase (GPx), Caspase-3, and Cytochrome c. Also, our study estimated their effect on Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Total Protein (T.P), Albumin (Alb), bilirubin, urea and creatinine.

Results: Azoles showed great increase in life span. Also, they showed a significant decrease in malondialdehyde and nitric oxide and an increase in catalase, glutathione peroxidase, caspase-3 activities, and cytochrome c concentration. Hence, it may be possible that Azoles decrease lipid peroxidation level due to their antioxidant effect and enhance apoptosis process. Azoles showed no side effects on liver and kidney. Also, they showed a significant protection for both liver and kidney histopathologically

Keywords: Antitumor activity; Erlich ascites carcinoma; Novel azoles; Triazole derivatives; Benzimidazole; Swiss albino mice