A New Approach in the Study of Hypertension in the
Elderly Subject: The Role of Epigenetics

Valerio Massimo Magro; Carla Coppola; Michele Caturano; Giovanni Scala; Walter Verrusio

Opinion

A New Approach in the Study of Hypertension in the Elderly Subject: The Role of Epigenetics

Valerio Massimo Magro*¹, Carla Coppola², Michele Caturano³, Giovanni Scala⁴ and Walter Verrusio⁵

¹Department of Internal Medicine and Geriatrics, Italy

²Department of Intensive Rehabilitation, Italy

³Department of Internal Medicine, Italy

⁴ASL RM2 Home Care Center, Rome

⁵Department of Cardiovascular, Italy

Corresponding Author

Received Date:January 18, 2019; Published Date: January 24, 2019

Abstract

Parkinson’s disease (PD) is a common neurodegenerative disorder with the pathological hallmark of progressive loss of dopamine neurons in affected brains. There is no cure for PD and current therapy does not halt the underlying degenerative process. The pathogenesis of PD is not fully understood but is likely caused by a combination of genetic and environmental factors. Several genes are associated with the onset and progression of familial PD. Mutations in LRRK2 are the most frequent known cause of lateonset PD. Many studies have been conducted to elucidate the functions of LRRK2 and identify effective LRRK2 inhibitors for PD treatment. In this review, I discuss the role of LRRK2 in PD and recent progress in studying LRRK2 cellular functions and the use of LRRK2 inhibitors as therapeutic agents.

Article Details

Citation

Valerio Massimo Magro, Carla Coppola, Michele Caturano, Giovanni Scala, Walter Verrusio. A New Approach in the Study of Hypertension in the Elderly Subject: The Role of Epigenetics. Arch Neurol & Neurosci. 2(4): 2019. ANN.MS.ID.000541.