Relationship between Vitamin D and Psoriasis

Psoriasis is a chronic inflammatory disease with immune involvement and increasing of keratinocytes in skin that manifest as dermatitis. Meanwhile, psoriasis is a systemic disease that affected other organs and can increase risk of metabolic disorders and chronic disease. Although, the etiology of psoriasis is not fully revealed but several factors such as genetic, auto-immunity and spiritual condition can affect presentation and development of disease.

Because vitamin D other than diet, is synthesized in the skin so it is proposed that this vitamin can affect cutaneous immune system. With regard to reports of many studies, vitamin D could have anti-proliferative and anti-inflammatory effects on skin diseases such as psoriasis. In many studies it is surveyed effects of topical therapy of vitamin D as adjunctive treatment in psoriasis and in a few of them performed in related to oral supplementation of this vitamin. Thus, it is necessary to represent effectiveness of vitamin D supplementation (as topical or oral) and reveal involvement mechanisms of this vitamin on psoriasis as a inflammatory skin disease.

Keywords:Auto-immunity, Inflammatory disease, Keratinocytes, Psoriasis, Vitamin D