Gut Microbiota and Modulating Immune Response
Received Date: October 12, 2020; Published Date: October 21, 2020
A healthy body has healthy gut microbiota. Unusual interactions between the microbiome and the host’s immune system in genetically susceptible individuals may contribute to the development of immune-mediated diseases. It is nearly 2kg of the host weight of the microbiome. Alteration of the microbiome, directly and indirectly, can significantly affect immune system regulation. The commensal gut microbiome plays a critical role to protect mucosal-immunity hemostasis. The intestinal tract has more resident immune cells such as the macrophages, dendritic cells, various subsets of T cells, B cells. In dysbiosis, disrupted epithelial barrier and leaky gut lead to inappropriate immune cell and gut microbiota interaction induce severe inflammation.