Gut Microbiota and Modulating
Immune Response

Somia Fathi Belal

Mini Review

Gut Microbiota and Modulating Immune Response

Shaghayegh Baradaran Ghavami*^{1^{, Maryam Farmani^{1^{, Shabnam Shahrokh^{1^{and Hamid Asadzadeh
Aghdaie^1,2}}}}}}

^{1^{Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti
University of Medical Sciences, Tehran, Iran}}

^{2^{Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical
Sciences, Tehran, Iran}}

Corresponding Author

Received Date: October 12, 2020; Published Date: October 21, 2020

Abstract

A healthy body has healthy gut microbiota. Unusual interactions between the microbiome and the host’s immune system in genetically susceptible individuals may contribute to the development of immune-mediated diseases. It is nearly 2kg of the host weight of the microbiome. Alteration of the microbiome, directly and indirectly, can significantly affect immune system regulation. The commensal gut microbiome plays a critical role to protect mucosal-immunity hemostasis. The intestinal tract has more resident immune cells such as the macrophages, dendritic cells, various subsets of T cells, B cells. In dysbiosis, disrupted epithelial barrier and leaky gut lead to inappropriate immune cell and gut microbiota interaction induce severe inflammation.

Article Details

Citation

Shaghayegh Baradaran Ghavami, Maryam Farmani, Shabnam Shahrokh. Gut Microbiota and Modulating Immune Response. Acad J Microbiol & Immun. 1(1): 2020. AJMI.MS.ID.000504.