Editorial
Understanding the Integrated Gene Regulatory Networks for Hepatocellular Carcinoma
Long Gao, Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Received Date: July 15, 2018; Published Date: July 27, 2018
Abstract
Hepatic cancer is a malignant tumor that begins in the cells of the liver. The leading cause is a viral infection with hepatitis B and hepatitis C. Hepatocellular carcinoma (HCC) has become the most common form of hepatic cancer. It is the fastest-growing cause of cancer deaths in the United States. HCC is also found to be associated with obesity, type 2 diabetes and fatty liver disease. To understand the gene expression regulation during HCC development, scientists have identified a few related transcription factors (TFs) and characterize their roles such as E2F1[1], Foxm1b [2] and hepatic nuclear factors [3]. However, these findings still cannot fully explain the underlying molecular mechanism during liver tumorigenesis. It is necessary to systematically study the global gene regulatory network (GRN) during HCC development.
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Long G. Understanding the Integrated Gene Regulatory Networks for Hepatocellular Carcinoma. Acad J Gastroenterol & Hepatol. 1(1): 2018. AJGH.MS.ID.000501.