Open Access Case Report

Complex Sources of Hyperbilirubinemia

Adel Ekladious1,2*, Lee Skeat1,3 and Ritesh Bhandari1

1Department of General Medicine, Royal Hobart Hospital, Australia

2Faculty of Health and Medical Sciences, University of Western Australia, Australia

3Facility of Medicine, University of Tasmania, Australia

Corresponding Author

Received Date: September 14, 2022;  Published Date: September 23, 2022


The authors present a case of a patient with severe hyperbilirubinemia due to acute hepatitis B infection which resolved without intervention with subsequent normalization of synthetic and excretory liver function. Despite this, the patient remained jaundiced due to unconjugated hyperbilirubinemia in the context of a recent diagnosis and flare of hereditary spherocytosis. Due to the complex clinical presentation, the patient underwent a liver biopsy with the additional genetic diagnosis of Gilbert’s Syndrome being established. This illustrates an unusual case of both Hepatitis B and hereditary spherocytosis being a potential cause for a flare of Gilbert Syndrome.

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