Perspectives of Photodynamic Therapy (PDT) as a Potential Therapeutic Intervention for Câncer

Photodynamic therapy (PDT) relies on the interaction between a photosensitizer, the appropriate wavelength, and oxygen leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vascular toxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well-designed clinical trials have demonstrated the efficacy of PDT on various cutaneous and deep tissue tumors. PDT has been widely used for many purposes’ great success. Although the therapeutic protocols regarding use of PDT in many diseases have not yet been standardized, and vary significantly between the different literature studies, PDT will likely continue to be explored thoroughly for use.

Keywords:Photodynamic therapy; Tumor; Cell death